THE HYPOXIA-DRIVEN CROSSTALK BETWEEN TUMOR AND TUMOR-ASSOCIATED MACROPHAGES: MECHANISMS AND CLINICAL TREATMENT STRATEGIES

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor develo

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Administrative contracts and administrative judication process

In this paper, administrative contracts and dispute resolution in administrative contracts are analysed.After a general introduction, the concept and characteristics of administrative contracts are discussed.Also, the regulation of administrative contracts according to the new Croatian administrative procedure law is presented.Then, the solutions o

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On the occurrence of the fireworm Eurythoe complanata complex (Annelida, Amphinomidae) in the Mediterranean Sea with an updated revision of the alien Mediterranean amphinomids

The presence of two species within the Eurythoe complanata complex in the Mediterranean Sea is reported, as well as their geographical distributions.One species, Eurythoe laevisetis, occurs in the eastern and central Mediterranean, likely constituting the first historical introduction to the Mediterranean Sea and the other, Eurythoe complanata, in

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